Steve speelde door de jaren heen enkele opmerkelijke rollen, waaronder in Reservoir Dogs en The Big Lebowski. De personages die Buscemi speelt zijn doorgaans neurotisch, paranoïde of onbetrouwbaar.

Steve is sinds 1987 getrouwd met Jo Andres, met wie hij in 1990 zoon Lucian kreeg.

Films

Grown Ups 2 (2013) - Wiley
Monsters University (2013) (stem) - Randall Boggs
The Incredible Burt Wonderstone (2013) - Anton Marvelton
Hotel Transylvania (2012) (stem) - Wayne
On the Road (2012)
Rampart (2011) - Bill Blago
Fight for Your Right Revisited (2011) - Waiter
Pete Smalls Is Dead (2010) - Bernie Lake
The Chosen One (2010) - Neal
Grown Ups (2010) - Wiley
Youth in Revolt (2009) - George Twisp
G-Force (2009) (stem) - Bucky
Saint John of Las Vegas (2009) - John
Handsome Harry (2009) - Thomas Kelley
Rage (2009) - Frank
John Rabe (2009) - Dr. Robert Wilson
The Messenger (2009) - Dale Martin
Igor (2008) (stem) - Scamper
I Now Pronounce You Chuck & Larry (2007) - Clint Fitzer
I Think I Love My Wife (2007) - George
Interview (2007) - Pierre Peders
Charlotte's Web (2006) (stem) - Templeton the Rat
Delirious (2006) - Les Galantine
Monster House (2006) (stem) - Nebbercracker
Paris, je t'aime (2006) - Le touriste (segment "Tuileries")
Art School Confidential (2006) - Broadway Bob D'Annunzio
Romance & Cigarettes (2005) - Angelo
The Island (2005) - James McCord
Who's the Top? (2005) - Cymon
Home on the Range (2004) (stem) - Wesley
Big Fish (2003) - Norther Winslow
Coffee and Cigarettes (2003) - Waiter (segment "Twins")
Spy Kids 3-D: Game Over (2003) - Romero
Spy Kids 2: Island of Lost Dreams (2002) - Romero
Mr. Deeds (2002) - Crazy Eyes
Love in the Time of Money (2002) - Martin Kunkle
13 Moons (2002) - Bananas The Clown
Domestic Disturbance (2001) - Ray Coleman
Monsters, Inc. (2001) (stem) - Randall Boggs
The Grey Zone (2001) - 'Hesch' Abramowics
Final Fantasy: The Spirits Within (2001) (stem) - Neil
Ghost World (2001) - Seymour
Double Whammy (2001) - Jerry Cubbins
28 Days (2000) - Cornell
Animal Factory (2000) - A.R. Hosspack
Big Daddy (1999) - Homeless Guy
Louis & Frank (1998) - Drexel
Armageddon (1998) - Rockhound
The Impostors (1998) - Happy Franks
The Big Lebowski (1998) - Theodore Donald 'Donny' Kerabatsos
The Wedding Singer (1998) - David 'Dave' Veltri
The Real Blonde (1997) - Nick
Con Air (1997) - Garland 'The Marietta Mangler' Greene
Escape from L.A. (1996) - Map to the Stars Eddie
Kansas City (1996) - Johnny Flynn
Trees Lounge (1996) - Tommy
Black Kites (1996) - The Father
Fargo (1996) - Carl Showalter
Things to Do in Denver When You're Dead (1995) - Mister Shhh
Desperado (1995) - Buscemi
Billy Madison (1995) - Danny McGrath
Living in Oblivion (1995) - Nick Reve
The Search for One-eye Jimmy (1994) - Ed Hoyt
Who Do I Gotta Kill? (1994)
Somebody to Love (1994) - Mickey
Airheads (1994) - Rex
Pulp Fiction (1994) - Buddy Holly
The Hudsucker Proxy (1994) - Beatnik Barman
Floundering (1994) - Ned
Ed and His Dead Mother (1993) - Ed Chilton
Rising Sun (1993) - Willy 'the Weasel' Wilhelm
Claude (1993) - Danny
Twenty Bucks (1993) - Frank
CrissCross (1992) - Louis
Reservoir Dogs (1992) - Mr. Pink
In the Soup (1992) - Aldolpho Rollo
What Happened to Pete (1992) - Stranger
Billy Bathgate (1991) - Irving
Barton Fink (1991) - Chet
Zandalee (1991) - OPP Man
Life Is Nice (1991) - Convienent Store Clerk
Miller's Crossing (1990) - Mink
King of New York (1990) - Test Tube
Force of Circumstance (1990)
Tales from the Darkside: The Movie (1990) - Bellingham (segment "Lot 249")
Mystery Train (1989) - Charlie the Barber (segment "Lost In Space")
Bloodhounds of Broadway (1989) - Whining Willie
Slaves of New York (1989) - Wilfredo
New York Stories (1989) - Gregory Stark (segment "Life Lessons")
Coffee and Cigarettes II (1989) - Waiter
Heart of Midnight (1988) - Eddy
Vibes (1988) - Fred
Call Me (1988) - Switchblade
Heart (1987) - Nicky
Arena Brains (1987) - The Agent
Kiss Daddy Goodnight (1987) - Johnny
No Picnic (1986) - Dead Pimp
Sleepwalk (1986) - Worker
Parting Glances (1986) - Nick
The Way It Is (1985) - Willy/Raphael
Tommy's (1985) - Tommy

Televisie

30 Rock - Lenny Wosniak (5 afleveringen, 2007-2012)
Boardwalk Empire - Enoch 'Nucky' Thompson (24 afleveringen, 2010-2011)
Portlandia - Book Store Customer (1 aflevering, 2011)
ER - Art Masterson (1 aflevering, 2008)
The Simpsons - Dwight (1 aflevering, 2007)
The Sopranos - Tony Blundetto / ... (16 afleveringen, 2002-2006)
The Laramie Project (2002) (TV) - Doc O'Connor
The Drew Carey Show - Mr. Marchetti (1 aflevering, 1998)
The Adventures of Pete & Pete - Phil Hickle (3 afleveringen, 1994-1996)
Homicide: Life on the Street - Gordon Pratt (1 aflevering, 1995)
The Last Outlaw (1993) - Philo
Tales from the Crypt - Ike (1 aflevering, 1993)
Mad About You - Howie Balenger (1 aflevering, 1992)
L.A. Law - David Lee (1 aflevering, 1991)
Against the Law - Timmy Lowell (1 aflevering, 1990)
Monsters - John Dennis (1 aflevering, 1990)
Borders (1989) - Ted
Lonesome Dove - Luke (4 afleveringen, 1989)
Crossbow - Captain of the Guard (1 aflevering, 1988)
The Equalizer - Archie, the Electronics Store Clerk (1 aflevering, 1987)
Miami Vice - Rickles (1 aflevering, 1986)
Not Necessarily the News - Neil (2 afleveringen, 1983-1986)

Video Game

Monsters, Inc. (2002) (stem) - Randall Boggs

Regisseur

30 Rock (2 afleveringen, 2009-2012)
Nurse Jackie (6 afleveringen, 2009-2011)
Interview (2007)
The Sopranos (4 afleveringen, 2001-2006)
Lonesome Jim (2005)
Baseball Wives (2002) (TV)
Oz (2 afleveringen, 1999-2001)
Animal Factory (2000)
Homicide: Life on the Street (1 aflevering, 1998)
Trees Lounge (1996)
What Happened to Pete (1992)

Producent

Vine Talk (uitvoerend producent) (1 aflevering, 2011)
Saint John of Las Vegas (2009) (uitvoerend producent)
Lonesome Jim (2005) (producent)
Symbiopsychotaxiplasm: Take 2 1/2 (2005) (uitvoerend producent)
Animal Factory (2000) (producent)

Schrijver

Interview (2007) (script)
Trees Lounge (1996)
What Happened to Pete (1992)